diff --git a/python/CMakeLists.txt b/python/CMakeLists.txt
index f0b6de07dd..a2e8f58d24 100644
--- a/python/CMakeLists.txt
+++ b/python/CMakeLists.txt
@@ -12,7 +12,7 @@ if(SKBUILD)
 endif()
 
 if(MATERIALX_INSTALL_PYTHON AND PYTHON_EXECUTABLE AND NOT SKBUILD)
-  set(SETUP_PY "${CMAKE_INSTALL_PREFIX}/python/setup.py")
-  configure_file("${CMAKE_CURRENT_SOURCE_DIR}/setup.py.in" "${SETUP_PY}")
+  set(PYPROJECT_TOML "${CMAKE_INSTALL_PREFIX}/python/pyproject.toml")
+  configure_file("${CMAKE_CURRENT_SOURCE_DIR}/pyproject.toml.in" "${PYPROJECT_TOML}")
   install(CODE "execute_process(COMMAND ${PYTHON_EXECUTABLE} -m pip install . WORKING_DIRECTORY ${CMAKE_INSTALL_PREFIX}/python)")
 endif()
diff --git a/python/MaterialX/MANIFEST.in b/python/MaterialX/MANIFEST.in
deleted file mode 100644
index 576179d13a..0000000000
--- a/python/MaterialX/MANIFEST.in
+++ /dev/null
@@ -1 +0,0 @@
-recursive-include libraries
diff --git a/python/pyproject.toml.in b/python/pyproject.toml.in
new file mode 100644
index 0000000000..f0f65abd6a
--- /dev/null
+++ b/python/pyproject.toml.in
@@ -0,0 +1,13 @@
+[build-system]
+requires = ["setuptools"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "MaterialX"
+version = "${MATERIALX_MAJOR_VERSION}.${MATERIALX_MINOR_VERSION}.${MATERIALX_BUILD_VERSION}"
+
+[tool.setuptools]
+packages = ["MaterialX"]
+
+[tool.setuptools.package-data]
+MaterialX = ["**/*"]
diff --git a/python/setup.py.in b/python/setup.py.in
deleted file mode 100644
index 072bafa968..0000000000
--- a/python/setup.py.in
+++ /dev/null
@@ -1,18 +0,0 @@
-from setuptools import setup
-import os
-
-os.chdir(os.path.dirname(os.path.abspath(__file__)))
-
-def getRecursivePackageData(root):
-    packageData = []
-    for dirpath, dirnames, filenames in os.walk(root):
-        relpath = os.path.relpath(dirpath, root)
-        packageData.append(os.path.join(relpath, '*.*'))
-    return packageData
-
-setup(name='MaterialX',
-      url='www.materialx.org',
-      version='${MATERIALX_MAJOR_VERSION}.${MATERIALX_MINOR_VERSION}.${MATERIALX_BUILD_VERSION}',
-      packages=['MaterialX'],
-      package_data={'MaterialX' : getRecursivePackageData('MaterialX')},
-      zip_safe = False)