diff --git a/xla/stream_executor/cuda/cuda_blas.cc b/xla/stream_executor/cuda/cuda_blas.cc
index cf946b68cae91..10c311e843097 100644
--- a/xla/stream_executor/cuda/cuda_blas.cc
+++ b/xla/stream_executor/cuda/cuda_blas.cc
@@ -1399,6 +1399,16 @@ absl::Status CUDABlas::GetVersion(std::string *version) {
 }
 
 void initialize_cublas() {
+  // Check if already registered before attempting - prevents duplicate
+  // registration error messages (can happen with multiple library loads)
+  auto already_registered = PluginRegistry::Instance()->HasFactory(
+      kCudaPlatformId, PluginKind::kBlas);
+  
+  if (already_registered) {
+    // Already registered, skip silently (mimics ROCm behavior)
+    return;
+  }
+  
   absl::Status status =
       PluginRegistry::Instance()->RegisterFactory<PluginRegistry::BlasFactory>(
           kCudaPlatformId, "cuBLAS",
diff --git a/xla/stream_executor/cuda/cuda_dnn.cc b/xla/stream_executor/cuda/cuda_dnn.cc
index 631b8489c22c7..7cc04ecacd11a 100644
--- a/xla/stream_executor/cuda/cuda_dnn.cc
+++ b/xla/stream_executor/cuda/cuda_dnn.cc
@@ -6947,6 +6947,16 @@ absl::Status CudnnGraph::PopulateOrUpdateRawCommandBuffer(
 }  // namespace gpu
 
 void initialize_cudnn() {
+  // Check if already registered before attempting - prevents duplicate
+  // registration error messages (can happen with multiple library loads)
+  auto already_registered = PluginRegistry::Instance()->HasFactory(
+      cuda::kCudaPlatformId, PluginKind::kDnn);
+  
+  if (already_registered) {
+    // Already registered, skip silently (mimics ROCm behavior)
+    return;
+  }
+  
   absl::Status status =
       PluginRegistry::Instance()->RegisterFactory<PluginRegistry::DnnFactory>(
           cuda::kCudaPlatformId, "cuDNN",
diff --git a/xla/stream_executor/cuda/cuda_fft.cc b/xla/stream_executor/cuda/cuda_fft.cc
index 5500b2c4586cd..54568733d4fe6 100644
--- a/xla/stream_executor/cuda/cuda_fft.cc
+++ b/xla/stream_executor/cuda/cuda_fft.cc
@@ -460,6 +460,16 @@ STREAM_EXECUTOR_CUDA_DEFINE_FFT(double, Z2Z, D2Z, Z2D)
 }  // namespace gpu
 
 void initialize_cufft() {
+  // Check if already registered before attempting - prevents duplicate
+  // registration error messages (can happen with multiple library loads)
+  auto already_registered = PluginRegistry::Instance()->HasFactory(
+      cuda::kCudaPlatformId, PluginKind::kFft);
+  
+  if (already_registered) {
+    // Already registered, skip silently (mimics ROCm behavior)
+    return;
+  }
+  
   absl::Status status =
       PluginRegistry::Instance()->RegisterFactory<PluginRegistry::FftFactory>(
           cuda::kCudaPlatformId, "cuFFT",