diff --git a/data/testResults/gene-essential.csv b/data/testResults/gene-essential.csv
index 21f17d16..c918efe0 100644
--- a/data/testResults/gene-essential.csv
+++ b/data/testResults/gene-essential.csv
@@ -1,7 +1,7 @@
 cellLine,TP,TN,FP,FN,accuracy,sensitivity,specificity,F1,MCC
-DLD1,39,2155,63,279,0.8651,0.1226,0.9716,0.1857,0.1588
-GBM,35,2134,67,299,0.8556,0.1048,0.9696,0.1606,0.128
-HCT116,49,2179,57,306,0.8599,0.138,0.9745,0.2126,0.1954
-HELA,32,2237,74,250,0.875,0.1135,0.968,0.1649,0.1281
-RPE1,15,2175,87,258,0.8639,0.05495,0.9615,0.08,0.026
-all,7,2375,99,112,0.9186,0.05882,0.96,0.06222,0.01988
+DLD1,50,2147,85,272,0.8602,0.1553,0.9619,0.2188,0.1739
+GBM,57,2138,78,280,0.8598,0.1691,0.9648,0.2415,0.2026
+HCT116,71,2179,70,289,0.8624,0.1972,0.9689,0.2834,0.2534
+HELA,35,2219,106,251,0.8633,0.1224,0.9544,0.1639,0.1061
+RPE1,21,2163,114,255,0.8555,0.07609,0.9499,0.1022,0.0361
+all,8,2357,133,113,0.9058,0.06612,0.9466,0.06107,0.01181
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
index c85322e5..fe801ce2 100644
--- a/model/Human-GEM.yml
+++ b/model/Human-GEM.yml
@@ -62692,7 +62692,7 @@
           - MAM02774m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303"
+      - gene_reaction_rule: "ENSG00000122971 or ENSG00000196177"
       - rxnFrom: "HMRdatabase"
       - eccodes:
           - "1.3.99.3"
@@ -63045,7 +63045,7 @@
           - MAM01803m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971 or ENSG00000151498 or ENSG00000177646 or ENSG00000196177 or ENSG00000240303"
+      - gene_reaction_rule: "ENSG00000122971 or ENSG00000196177"
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.3.99.3"
       - references: "PMID:13295225;PMID:3597357"
@@ -71033,7 +71033,7 @@
           - MAM02468m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000122971 or ENSG00000196177"
+      - gene_reaction_rule: "ENSG00000151498 or ENSG00000122971 or ENSG00000196177"
       - rxnFrom: "HMRdatabase"
       - eccodes:
           - "1.3.8.5"
@@ -71122,7 +71122,7 @@
           - MAM02999m: 1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000122971 or ENSG00000196177"
+      - gene_reaction_rule: "ENSG00000151498 or ENSG00000122971 or ENSG00000196177"
       - rxnFrom: "HMRdatabase"
       - eccodes:
           - "1.3.8.5"
@@ -96075,7 +96075,7 @@
           - MAM02630m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
+      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000177646"
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.3.3.6"
       - references: "PMID:12054595"
@@ -96315,7 +96315,7 @@
           - MAM02630m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000087008 or ENSG00000161533"
+      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000177646"
       - rxnFrom: "HMRdatabase"
       - eccodes: "1.3.3.6"
       - references: "PMID:11368003;PMID:9862787"
@@ -105177,13 +105177,14 @@
           - MAM01803m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000117054 or ENSG00000177646"
+      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000177646 or ENSG00000240303"
       - rxnFrom: "HMRdatabase"
       - eccodes:
           - "1.3.8.7"
           - "1.3.8.8"
           - "1.3.8.9"
           - "1.3.99.-"
+      - references: "PMID:21237683"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -105245,13 +105246,14 @@
           - MAM01803m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000117054 or ENSG00000177646"
+      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361 or ENSG00000177646 or ENSG00000240303"
       - rxnFrom: "HMRdatabase"
       - eccodes:
           - "1.3.8.7"
           - "1.3.8.8"
           - "1.3.8.9"
           - "1.3.99.-"
+      - references: "PMID:21237683"
       - subsystem:
           - "Beta oxidation of even-chain fatty acids (mitochondrial)"
       - confidence_score: 0
@@ -200147,7 +200149,7 @@
           - MAM03333m: -1
       - lower_bound: -1000
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000115361 or ENSG00000117054 or ENSG00000196177"
+      - gene_reaction_rule: "ENSG00000115361"
       - rxnFrom: "Recon3D"
       - eccodes: "1.3.99.3"
       - references: "PMID:1047780;PMID:11135616;PMID:8973539"
@@ -203271,7 +203273,7 @@
           - MAM03352m: -1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000161533"
+      - gene_reaction_rule: "ENSG00000072778 or ENSG00000115361"
       - rxnFrom: "Recon3D"
       - eccodes: "1.3.3.6"
       - references: "PMID:11356164;PMID:7775433"