diff --git a/docs/disciplines/Bioinformatics/.pages b/docs/disciplines/Bioinformatics/.pages index d4c1345ed..907e5ad45 100644 --- a/docs/disciplines/Bioinformatics/.pages +++ b/docs/disciplines/Bioinformatics/.pages @@ -3,4 +3,5 @@ title: Bioinformatics nav: - index.md - 'Data Types': Data_Types - - 'Tools': Tools \ No newline at end of file + - 'Tools': Tools + - 'Methods': Methods \ No newline at end of file diff --git a/docs/disciplines/Bioinformatics/Methods/survival_analysis.md b/docs/disciplines/Bioinformatics/Methods/survival_analysis.md new file mode 100644 index 000000000..1d0e29054 --- /dev/null +++ b/docs/disciplines/Bioinformatics/Methods/survival_analysis.md @@ -0,0 +1,40 @@ +# Survival Analysis + +Survival analysis is a key statistical approach used to study time-to-event outcomes like time until disease progression, relapse, or death. Unlike traditional regression methods, survival analysis accounts for censoring (patients lost to follow-up or still alive at study end) and allows estimation of event probabilities over time. + +Survival analysis is often used to: + +- Evaluate the impact of potential biomarkers on treatment response and patient outcomes. + +- Compare survival curves across patient subgroups (e.g., different mutation profiles, treatments, methods in multicentre studies, etc.). + +- Identify predictive markers of drug benefit or toxicity. + +- Build models that can use multiomic data to guide precision medicine. + +Commonly used methods include: + +- **Kaplan–Meier curves**: non-parametric estimates of survival probabilities over time. + +- **Cox proportional hazards models**: regression framework to evaluate covariates (e.g., gene mutations, drug classes) affecting hazard rates. + +- **Random survival forests / survival support vector machines / deep learning survival models**: machine learning approaches that can capture complex interactions in high-dimensional omics datasets. + +Recommended Learning Resources + +- 🎥 **Video Playlist** - [Survival Analysis | Concepts and Implementation in R (YouTube)](https://www.youtube.com/playlist?list=PLqzoL9-eJTNDdnKvep_YHIwk2AMqHhuJ0) + + Great introduction to both fundamentals and applied examples in R. + +- 📘 **Tutorial in R** – [Survival Analysis in R](https://www.emilyzabor.com/survival-analysis-in-r.html) [| Slide](https://www.emilyzabor.com/talks.html) + + Hands-on guidance with code snippets. + +- 📄 **Articles** + * [An Introduction to Survival Statistics: Kaplan–Meier Analysis (PMC)](https://pmc.ncbi.nlm.nih.gov/articles/PMC5045282/) + Clear explanation of Kaplan–Meier methodology with biomedical applications. + * [Survival Analysis Part I: Basic concepts and first analyses](https://pmc.ncbi.nlm.nih.gov/articles/PMC2394262/) + [Survival Analysis Part II: Multivariate data analysis – an introduction to concepts and methods](https://pmc.ncbi.nlm.nih.gov/articles/PMC2394368/) + [Survival Analysis Part III: Multivariate data analysis – choosing a model and assessing its adequacy and fit](https://pmc.ncbi.nlm.nih.gov/articles/PMC2376927/) + [Survival Analysis Part IV: Further concepts and methods in survival analysis](https://pmc.ncbi.nlm.nih.gov/articles/PMC2394469/) + A four-part series covering basic methods and terminology in survival analysis. Frequently asked questions are addressed in Part IV.