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Hi Brinkmanlab,
Regarding your message:
"Please note that IslandPath-DIMOB predictions should only take a couple of minutes per bacterial genome. It was recently reported that IslandPath-DIMOB was extremely slow on Mac OS X with a conda installation of perl libraries."
I faced this problem, e.g., the example NC00320 took 3 hours to complete the hmmscan with --cpu 20.
My installation: I git clone the repository and install the dependencies via conda.
The only way I could fix it was by moving all the cloned repositories from a subdirectory (/mnt/c/...) to the root.... (~/)
Apparently, there was a I/O bottleneck when running in /mnt/c/ under WSL.... Just by moving the files, the example took seconds...
I hope this message helps others...
Best,
Ricardo