Average concentration calculation using AUCall

[Sibojang9]

The R function pk.calc.cav() seems to use the AUClast for the calculation, which is an issue for me when the data have some BLQ points.

function (auc, start, end) 
{
    ret <- auc/(end - start)
    mask_zero <- is.na(end) | is.na(start) | end == start
    if (any(mask_zero)) {
        ret[mask_zero] <- NA_real_
    }
    ret
}

I am wondering if there is a function to use the AUCall for the calculation of Cave. AUClast can underestimate the Cave since it does not include the AUC from the last >LLOQ point to zero concentration data point over the specified interval.

[billdenney]

Hi @Sibojang9 , the function is used to calculate Cav in many different ways where the AUC is replaced by different AUC values dependent on which you want to use.

Is the parameter cav.int.all what you're looking for?