AUC0-tau differ from those calculated by WinNonlin,how to solve it?

[Su-2020]

I am a statistician. Recently, while using the pknca package, I noticed that the results for AUC0-tau differ from those calculated by WinNonlin. Previously, when calculating AUC0-last, I encountered a similar issue, which was resolved by setting AUC method = linear in the options. Could you please advise on how to resolve this? In theory, since I set it to linear, it should also apply to the calculation of AUC0-tau.

[billdenney]

Before running pk.nca(), you can set the AUC integration method to linear using one of these two methods:

1. (preferred) Use the options argument to PKNCAdata(): PKNCAdata(conc_obj, intervals = intervals, options = list(auc.method = "linear"))
2. (also works) Use PKNCA.options(auc.method = "linear") before calling pk.nca()

[Su-2020]

I had set it,but still not work. just wonder why occur this ?

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------------------ 原始邮件 ------------------ 发件人: "humanpred/pknca" ***@***.***>; 发送时间: 2025年6月9日(星期一) 晚上7:00 ***@***.***>; ***@***.******@***.***>; 主题: Re: [humanpred/pknca] AUC0-tau differ from those calculated by WinNonlin,how to solve it? (Discussion #431) Before running pk.nca(), you can set the AUC integration method to linear using one of these two methods: (preferred) Use the options argument to PKNCAdata(): PKNCAdata(conc_obj, intervals = intervals, options = list(auc.method = "linear")) (also works) Use PKNCA.options(auc.method = "linear") before calling pk.nca() — Reply to this email directly, view it on GitHub, or unsubscribe. You are receiving this because you authored the thread.Message ID: ***@***.***>

[billdenney]

Can you please provide a reproducible example (with made-up data, if necessary) that shows the disconnect?

[Su-2020]

if you have new progress, let me know.Thanks

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------------------ 原始邮件 ------------------ 发件人: "humanpred/pknca" ***@***.***>; 发送时间: 2025年6月9日(星期一) 晚上7:09 ***@***.***>; ***@***.******@***.***>; 主题: Re: [humanpred/pknca] AUC0-tau differ from those calculated by WinNonlin,how to solve it? (Discussion #431) Can you please provide a reproducible example (with made-up data, if necessary) that shows the disconnect? — Reply to this email directly, view it on GitHub, or unsubscribe. You are receiving this because you authored the thread.Message ID: ***@***.***>

[billdenney]

I don't know exactly what solution you're looking for without a reproducible example. Can you please provide an example with what is happening and what is different than you expect?