How to choose the most appropriate options to interpolate concentrations between measurements or extrapolate concentrations after the last measurement

[ChunLIU001]

Hi Bill,

I want to calculate partial AUC (e.g., AUC0-28d) by using PKNCA. I see there are 3 methods ('lin up/log down', 'lin-log', or 'linear') to interpolate the missing observations and 3 methods to extrapolate concentrations after the last measurement ('AUCinf', 'AUClast', and 'AUCall'). Is there any guidance to help me select the most appropriate method to fit my data (e.g., drug was given by a 10min iv infusion, single dose), please?

Best regards,
Chun