diff --git a/dev-python/m2crypto/Manifest b/dev-python/m2crypto/Manifest
index c59b22254a..4ba349f0a8 100644
--- a/dev-python/m2crypto/Manifest
+++ b/dev-python/m2crypto/Manifest
@@ -1 +1,2 @@
 DIST m2crypto-0.44.0.tar.gz 363805 BLAKE2B 0a61574ebee8a82ff2b00fa595870fe8d7e965be893db1e82bd1796703ecec16d7c476185b4b4db754efee1e698f60f20c783d1da04f77ee604afb9a346a2077 SHA512 8f8e9d88852eb003eaad9242ca43a0218354d9af3a6f0d9666ceba0ef2c840cd0aca0ad8493a222eb1de9dd0253c0204dde5530fd6a59ee1c3f29be83ec23458
+DIST m2crypto-0.45.1.tar.gz 363721 BLAKE2B a2e1d78e65825e8ae13196aed8ea902618536a3607670a1b4900fbe5cd893d5badfd0431f6b594a209e49088ffbf6ea3540863a6ee2162ac230742d442322262 SHA512 7915bbb63625f645b6281dbdd2bb60691a6fa0d54ab505a1105d76efad5e0407ce68e38bebd5e0b0773bcbb99025ff7aa7d8df25fe32364d4a33471e6e9466ce
diff --git a/dev-python/m2crypto/m2crypto-0.45.1.ebuild b/dev-python/m2crypto/m2crypto-0.45.1.ebuild
new file mode 100644
index 0000000000..e8e69e7050
--- /dev/null
+++ b/dev-python/m2crypto/m2crypto-0.45.1.ebuild
@@ -0,0 +1,48 @@
+# Distributed under the terms of the GNU General Public License v2
+
+EAPI=7
+
+PYTHON_COMPAT=( python3+ pypy3 )
+inherit distutils-r1 toolchain-funcs
+
+DESCRIPTION="A Python crypto and SSL toolkit"
+HOMEPAGE="https://gitlab.com/m2crypto/m2crypto https://pypi.org/project/M2Crypto/"
+SRC_URI="https://files.pythonhosted.org/packages/ad/69/33db804ea9c50175df3508d97bd3c33926913480bbd951008b92f678b138/m2crypto-0.45.1.tar.gz -> m2crypto-0.45.1.tar.gz"
+
+DEPEND=""
+RDEPEND="
+	libressl? ( dev-libs/libressl:0= )
+	!libressl? ( dev-libs/openssl:0= )
+	virtual/python-typing[$PYTHON_USEDEP]"
+BDEPEND="
+	>=dev-lang/swig-2.0.9"
+IUSE="libressl"
+SLOT="0"
+LICENSE="MIT"
+KEYWORDS="*"
+S="${WORKDIR}/m2crypto-0.45.1"
+
+swig_define() {
+	local x
+	for x; do
+		if tc-cpp-is-true "defined(${x})"; then
+			SWIG_FEATURES+=" -D${x}"
+		fi
+	done
+}
+python_compile() {
+	# setup.py looks at platform.machine() to determine swig options.
+	# For exotic ABIs, we need to give swig a hint.
+	local -x SWIG_FEATURES=
+
+	# https://bugs.gentoo.org/617946
+	swig_define __ILP32__
+
+	# https://bugs.gentoo.org/674112
+	swig_define __ARM_PCS_VFP
+
+	distutils-r1_python_compile
+}
+python_test() {
+	esetup.py test
+}