Focusrite 8i6 Guitar has sound but there is a constant loud buzzing like an amp is turned up way too high

[Jacobugath44]

for "EnableWasapiOutputs" you can use -1 to have a message prompting

to use either WASAPI or ASIO for output every time you boot the game

[Config]
EnableWasapiOutputs=1
EnableWasapiInputs=0
EnableAsio=1

[Asio]
; available buffer size modes:
; driver - respect buffer size setting set in the driver
; host - use a buffer size as close as possible as that requested by the host application
; custom - use the buffer size specified in CustomBufferSize field
BufferSizeMode=custom
CustomBufferSize=240

if your game hangs or crashes on exit, try setting "EnableRefCountHack" to true.

when blank or invalid, the value of "EnableRefCountHack" will be interpreted as

true if RS ASIO detects the usage of Asio4All.

the same applies for all inputs.

[Asio.Output]
Driver=Focusrite USB ASIO
BaseChannel=0
AltBaseChannel=
EnableSoftwareEndpointVolumeControl=1
EnableSoftwareMasterVolumeControl=1
SoftwareMasterVolumePercent=100
EnableRefCountHack=

[Asio.Input.0]
Driver=Focusrite USB ASIO
Channel=1
EnableSoftwareEndpointVolumeControl=1
EnableSoftwareMasterVolumeControl=1
SoftwareMasterVolumePercent=100
EnableRefCountHack=

[Asio.Input.1]
Driver=
Channel=1
EnableSoftwareEndpointVolumeControl=1
EnableSoftwareMasterVolumeControl=1
SoftwareMasterVolumePercent=100
EnableRefCountHack=

[Asio.Input.Mic]
Driver=
Channel=1
EnableSoftwareEndpointVolumeControl=1
EnableSoftwareMasterVolumeControl=1
SoftwareMasterVolumePercent=100
EnableRefCountHack=

[mdias]

CustomBufferSize=240

Why are you using this value? This is unlikely to work well.
Instead please try 256 or 192.

Also, have you tried recording or using your guitar with any other software to double check the interface if working fine?