Erythrocyte glycolytic and redox metabolism affects muscle oxygenation and exercise performance: a randomized double-blind crossover study in men

This repository corresponds to our paper, titled "Erythrocyte glycolytic and redox metabolism affects muscle oxygenation and exercise performance: a randomized double-blind crossover study in men", which has been published in Sports Medicine. In this study, we investigated the role of erythrocyte redox metabolism in exercise fatigue using in vivo, ex vivo and computational analyses.

Contact

• Panagiotis N. Chatzinikolaou
• Twitter handle: https://twitter.com/PanosChatz1
• Personal website: panos-chatz.netlify.app
• Email: chatzinpn@phed-sr.auth.gr
• ORCID ID: https://orcid.org/0000-0002-8136-1638

Repository structure

• analysis_docs/

  • Contains Quarto Markdown (.qmd) files documenting:
    • 01_Data_Preparation.qmd: Data cleaning, processing and reshaping from wide to long format for analysis.
    • 02_Figures.qmd: Code for visualizing the data in figures and panels.
    • 03_Statistics.qmd: Statistical analyses (repeated measures anova, post-hocs, parametric and non-parametric t-tests, and effect sizes).

• data/

  • Includes raw and processed data files:
    • complete_database.csv: Dataset in wide format in CSV.
    • tidyData.RData: Data in tidy/long format.
  • README.md: Documentation for the data files.

• quantitative_analysis/

  • Scripts and results for quantitative analysis:
    • ODC plots.R: R script for calculating p50 values and plotting Oxygen Dissociation Curves.
    • p50_analysis.R: Statistical analysis of p50 values.

• r_docs/

  • Custom helper functions for statistics:
    • MyCohensEffSizes.R: Functions for calculating Cohen's effect sizes.
    • MyStatsFunctions.R: Summary statistics functions.
  • README.md: Documentation for the R scripts.

License

This project uses a CC-BY 4.0 license. All code is additionally licensed under an MIT license.