Genome-scale metabolic model of the non-conventional yeast Sungouiella intermedia (formerly Candida intermedia), reconstructed for investigation of its lactose and galactose metabolism and its potential as a future cell factory on lactose-rich industrial side-streams.
Peri, K.. V. R., Domenzain, I. et al (2025). Model-Driven Elucidation of Lactose and Galactose Metabolism via Oxidoreductive Pathway in Sungouiella intermedia for Cell Factory Applications. bioRXIV, 2024. doi:2024.11.19.624258
Utilisation: experimental data reconstruction; multi-omics integrative analysis
Field: metabolic-network reconstruction
Type of model: curated
Model source: YeastMetabolicNetwork
Omic source: genomics; transcriptomics; HPLC cultivation data
Taxonomic name: Sungouiella intermedia
Taxonomy ID: taxonomy:45354
Genome ID: insdc.gca:GCA_900106125.1
Metabolic system: general metabolism
Strain: PYCC 4715
Condition: general
This approach is recommended, but requires git to be installed In Terminal/Command Prompt, navigate to the desired installation directory and run the following Git command:
git clone --depth=1 https://github.com/SysBioChalmers/sint-GEM .git
To reproduce the sint-GEM reconstruction process just navigate to the code directory in this repository using MATLAB, then run the reconstruction script by typing the following in the MATLAB command window:
generate_sintGEM
The resulting model files are stored in the sint-GEM/model directory in .MAT, SBML and .txt files to facilitate accessibility and distribution.
The model is stored and distributed both in SBML and MATLAB formats to enable utilisation with any of the standard constraint-based toolboxes such as COBRA, RAVEN and cobraPy.
Contributions are always welcome! Please read the contributing guideline to get started.
Code contributors are reported automatically by GitHub under Contributors, while other contributions come in as Issues.