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Hae Kyung Im edited this page Mar 22, 2016 · 3 revisions

Pilot Project I

  • find and download HapMap2 genotype data for CEU, YRI, and ASN (CHB and JPT) populations in plink format (use the one with all populations combined)

  • use GCTA to calculate eigenvectors y eigenvalues of the hapmap genotype data

  • plot the first few eigenvectors against each other

  • download intrinsic growth data and run GWAS using plink (Table S1 from http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002525 - you may need to add a family id column to this file when running plink)

  • re-run GWAS using the first 2 eigenvectors of genotype data as covariates

  • write a short report describing what you have done

  • Present results

Pilot Project 2

  • find and download HapMap2 genotype data for CEU, YRI, and ASN (CHB and JPT) populations in plink format (use the one with all populations combined)

  • use GCTA to calculate eigenvectors y eigenvalues of the hapmap genotype data

  • plot the first few eigenvectors against each other

  • create a “phenotype” that is 1 if the individual belongs to CEU and for the other populations

  • run GWAS using plink for this phenotype

  • run GWAS again using the first 2 eigenvectors obtained with GCTA

  • write a short report

  • present

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